{"id":1091,"date":"2024-04-03T20:47:08","date_gmt":"2024-04-03T20:47:08","guid":{"rendered":"https:\/\/axt.ccw.mybluehost.me\/?page_id=1091"},"modified":"2024-09-27T18:02:32","modified_gmt":"2024-09-27T18:02:32","slug":"research","status":"publish","type":"page","link":"https:\/\/junelab.org\/ron\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1091\" class=\"elementor elementor-1091\">\n\t\t\t\t<div class=\"elementor-element elementor-element-483750b e-flex e-con-boxed e-con e-parent\" data-id=\"483750b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ccc0d23 elementor-widget elementor-widget-image\" data-id=\"ccc0d23\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"511\" src=\"https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/knees-768x511.jpg\" class=\"attachment-medium_large size-medium_large wp-image-1377\" alt=\"\" srcset=\"https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/knees-768x511.jpg 768w, https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/knees-300x200.jpg 300w, https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/knees-1024x681.jpg 1024w, https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/knees-1536x1022.jpg 1536w, https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/knees-2048x1363.jpg 2048w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3ce1d095 e-flex e-con-boxed e-con e-parent\" data-id=\"3ce1d095\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7b3baecb e-con-full e-flex e-con e-child\" data-id=\"7b3baecb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-13881f69 e-flex e-con-boxed e-con e-child\" data-id=\"13881f69\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-5596b5e2 e-con-full e-flex e-con e-child\" data-id=\"5596b5e2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-abe986f elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"abe986f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Research<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-755065e7 e-con-full e-flex e-con e-child\" data-id=\"755065e7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6fe68986 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6fe68986\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12a33458 elementor-widget elementor-widget-text-editor\" data-id=\"12a33458\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #333333; font-family: 'Open Sans', Verdana, Geneva, sans-serif; font-size: 14px;\">Our research is in the area of osteoarthritis, which is an aging-related disease in which cartilage deteriorates resulting in painful joints and decreased mobility.\u00a0Our long term goal is to develop novel treatment strategies which utilize protein transduction and build upon developed knowledge involving chondrocyte mechanotransduction.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-68af30d2 e-flex e-con-boxed e-con e-child\" data-id=\"68af30d2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-8aa8c11 e-flex e-con-boxed e-con e-child\" data-id=\"8aa8c11\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-201467b elementor-widget__width-inherit elementor-widget elementor-widget-image\" data-id=\"201467b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"750\" height=\"184\" src=\"https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/research_program-msu.png\" class=\"attachment-large size-large wp-image-1267\" alt=\"Osteoarthritis research\" srcset=\"https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/research_program-msu.png 750w, https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/research_program-msu-300x74.png 300w\" sizes=\"(max-width: 750px) 100vw, 750px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-41687301 e-flex e-con-boxed e-con e-child\" data-id=\"41687301\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-16e0215d elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"16e0215d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" src=\"https:\/\/junelab.org\/wp-content\/uploads\/elementor\/thumbs\/laboratory-medical-medicine-3827738-qmmaevx8esojxbjskoum66qusitr12qdf5ixv9p65i.jpg\" title=\"laboratory-medical-medicine-3827738\" alt=\"laboratory, medical, medicine-3827738.jpg\" loading=\"lazy\" \/><\/figure><div class=\"elementor-image-box-content\"><h4 class=\"elementor-image-box-title\">Synovial Joint Drug Delivery<\/h4><p class=\"elementor-image-box-description\">One roadblock for treating degenerative joint disorders is very short joint residence times for most molecules upon injection into the joint.  We are interested in using and modifying Protein Transduction Domains to improve the joint residence times of therapeutic cargo toward developing effective treatments for osteoarthritis and other joint disorders.\n\n<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28cf4c9b elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"28cf4c9b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" src=\"https:\/\/junelab.org\/wp-content\/uploads\/elementor\/thumbs\/lab-analysis-diagnostics-2815639-qmmaevx8esojxbjskoum66qusitr12qdf5ixv9p65i.jpg\" title=\"lab-analysis-diagnostics-2815639\" alt=\"lab, analysis, diagnostics-2815639.jpg\" loading=\"lazy\" \/><\/figure><div class=\"elementor-image-box-content\"><h4 class=\"elementor-image-box-title\">Cellular Mechanotransduction<\/h4><p class=\"elementor-image-box-description\">All cells are subjected to mechanical loads from interactions with their environments (e.g. walking or gravity).  Several studies have demonstrated that cells change their biological behavior in response to mechanical loading.  We use chondrocytes (cartilage cells) as a model system and are interested in using a systems biology approach to understand how both chondrocytes and other cells respond to mechanical loading.\n\n<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-75a5f0a e-con-full e-flex e-con e-child\" data-id=\"75a5f0a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6e601b6 elementor-widget elementor-widget-image\" data-id=\"6e601b6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"350\" height=\"159\" src=\"https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/Approach-sm.png\" class=\"attachment-large size-large wp-image-1330\" alt=\"Approach\" srcset=\"https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/Approach-sm.png 350w, https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/Approach-sm-300x136.png 300w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-95b750f e-flex e-con-boxed e-con e-child\" data-id=\"95b750f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-ad72075 e-con-full e-flex e-con e-child\" data-id=\"ad72075\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-458e4cf elementor-widget elementor-widget-heading\" data-id=\"458e4cf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Approach<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5fc5036 e-con-full e-flex e-con e-child\" data-id=\"5fc5036\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-752df0d elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"752df0d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-14b8a07 elementor-widget elementor-widget-text-editor\" data-id=\"14b8a07\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-align: var(--text-align); background-color: var( --e-global-color-astglobalcolor5 );\">Our first research area, cellular mechanotransduction, is related to our objective to learn how cells respond to mechanical cues. Our second research area, synovial joint drug delivery, is tied to the objective of a bioactive intraarticular delivery platform. As shown in the diagram above, we expect that by conducting research in these two areas, we will reach both objectives and ultimately fullfil our long term goal of developing novel strategies for treating joint disease.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dae5514 e-flex e-con-boxed e-con e-parent\" data-id=\"dae5514\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2e98b265 e-con-full e-flex e-con e-child\" data-id=\"2e98b265\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-529de0e7 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"529de0e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c82f885 elementor-widget elementor-widget-heading\" data-id=\"4c82f885\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Want to know more about working with us at MSU? Click here.<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Our research is in the area of osteoarthritis, which is an aging-related disease in which cartilage deteriorates resulting in painful joints and decreased mobility.\u00a0Our long term goal is to develop novel treatment strategies which utilize protein transduction and build upon developed knowledge involving chondrocyte mechanotransduction. Synovial Joint Drug Delivery One roadblock for treating degenerative [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"nf_dc_page":"","site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1091","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/pages\/1091","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/comments?post=1091"}],"version-history":[{"count":8,"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/pages\/1091\/revisions"}],"predecessor-version":[{"id":1515,"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/pages\/1091\/revisions\/1515"}],"wp:attachment":[{"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/media?parent=1091"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}