{"id":1523,"date":"2024-09-27T18:51:20","date_gmt":"2024-09-27T18:51:20","guid":{"rendered":"https:\/\/axt.ccw.mybluehost.me\/?page_id=1523"},"modified":"2024-09-27T18:53:34","modified_gmt":"2024-09-27T18:53:34","slug":"cartilage-chondrocyte-mechanotransduction","status":"publish","type":"page","link":"https:\/\/junelab.org\/ron\/research\/cartilage-chondrocyte-mechanotransduction\/","title":{"rendered":"Cartilage &#038; Chondrocyte Mechanotransduction"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1523\" class=\"elementor elementor-1523\">\n\t\t\t\t<div class=\"elementor-element elementor-element-12d1c2f9 e-flex e-con-boxed e-con e-parent\" data-id=\"12d1c2f9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-74e2fc94 e-con-full e-flex e-con e-child\" data-id=\"74e2fc94\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3ea5f3ca elementor-widget elementor-widget-heading\" data-id=\"3ea5f3ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Cartilage &amp; Chondrocyte Mechanotransduction<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6e20d90a e-flex e-con-boxed e-con e-parent\" data-id=\"6e20d90a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-52efa0e e-con-full e-flex e-con e-child\" data-id=\"52efa0e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-2ceecb2d e-flex e-con-boxed e-con e-child\" data-id=\"2ceecb2d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-14d4d962 e-con-full e-flex e-con e-child\" data-id=\"14d4d962\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1ba3bf73 elementor-widget elementor-widget-image\" data-id=\"1ba3bf73\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"665\" height=\"502\" src=\"https:\/\/junelab.org\/wp-content\/uploads\/2024\/09\/chonmdrocyte-mechanotransdution-june1.jpg\" class=\"attachment-full size-full wp-image-1526\" alt=\"chondro\" srcset=\"https:\/\/junelab.org\/wp-content\/uploads\/2024\/09\/chonmdrocyte-mechanotransdution-june1.jpg 665w, https:\/\/junelab.org\/wp-content\/uploads\/2024\/09\/chonmdrocyte-mechanotransdution-june1-300x226.jpg 300w\" sizes=\"(max-width: 665px) 100vw, 665px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f5a25fc e-con-full e-flex e-con e-child\" data-id=\"7f5a25fc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-57c3fe8d elementor-vertical-align-middle elementor-widget-mobile__width-inherit elementor-widget elementor-widget-image-box\" data-id=\"57c3fe8d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Cartilage &amp; Chodrocyte Mechanotransduction<\/h3><p class=\"elementor-image-box-description\">**Enter your text here** All cells are subjected to mechanical loads from interactions with their environments (e.g. walking or gravity).  Several studies have demonstrated that cells change their biological behavior in response to mechanical loading.  We use chondrocytes (cartilage cells) as a model system and are interested in using a systems biology approach to understand how both chondrocytes and other cells respond to mechanical loading. \n\ncellular mechanotransduction, is related to our objective to learn how cells respond to mechanical cues. Our second research area, synovial joint drug delivery, is tied to the objective of a bioactive intraarticular delivery platform. As shown in the diagram above, we expect that by conducting research in these two areas, we will reach both objectives and ultimately fulfill our long term goal of developing novel strategies for treating joint disease.\n\n\n\n\n<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6f90d477 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6f90d477\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-113e16d e-flex e-con-boxed e-con e-child\" data-id=\"113e16d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d79d527 e-con-full e-flex e-con e-child\" data-id=\"d79d527\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7094285d elementor-vertical-align-middle elementor-widget-mobile__width-inherit elementor-widget elementor-widget-image-box\" data-id=\"7094285d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Additional Headers<\/h3><p class=\"elementor-image-box-description\">**Enter your text here** Sed et tempor neque. Pellentesque at justo ac erat fermentum mattis. Aenean libero metus, posuere finibus venenatis sed, accumsan id velit. Vivamus sed nisi non ipsum faucibus tincidunt. \n<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-178a2920 e-con-full e-flex e-con e-child\" data-id=\"178a2920\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6bbd659f elementor-widget elementor-widget-image\" data-id=\"6bbd659f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1280\" height=\"853\" src=\"https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/laboratory-medical-medicine-3827738.jpg\" class=\"attachment-full size-full wp-image-1124\" alt=\"laboratory, medical, medicine-3827738.jpg\" srcset=\"https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/laboratory-medical-medicine-3827738.jpg 1280w, https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/laboratory-medical-medicine-3827738-300x200.jpg 300w, https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/laboratory-medical-medicine-3827738-1024x682.jpg 1024w, https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/laboratory-medical-medicine-3827738-768x512.jpg 768w\" sizes=\"(max-width: 1280px) 100vw, 1280px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-103a729c elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"103a729c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-63a8300d e-flex e-con-boxed e-con e-child\" data-id=\"63a8300d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-145cd192 e-con-full e-flex e-con e-child\" data-id=\"145cd192\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-11beaaac elementor-widget elementor-widget-image\" data-id=\"11beaaac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1280\" height=\"720\" src=\"https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/mitosis-meiosis-cell-3876669.jpg\" class=\"attachment-full size-full wp-image-1348\" alt=\"mitosis, meiosis, cell-3876669.jpg\" srcset=\"https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/mitosis-meiosis-cell-3876669.jpg 1280w, https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/mitosis-meiosis-cell-3876669-300x169.jpg 300w, https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/mitosis-meiosis-cell-3876669-1024x576.jpg 1024w, https:\/\/junelab.org\/wp-content\/uploads\/2024\/04\/mitosis-meiosis-cell-3876669-768x432.jpg 768w\" sizes=\"(max-width: 1280px) 100vw, 1280px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4dbb4d1 e-con-full e-flex e-con e-child\" data-id=\"4dbb4d1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3b91fd94 elementor-vertical-align-middle elementor-widget-mobile__width-inherit elementor-widget elementor-widget-image-box\" data-id=\"3b91fd94\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Additional Headers &amp; Images<\/h3><p class=\"elementor-image-box-description\">**Enter your text here** Sed et tempor neque. Pellentesque at justo ac erat fermentum mattis. Aenean libero metus, posuere finibus venenatis sed, accumsan id velit. Vivamus sed nisi non ipsum faucibus tincidunt. \n\n<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Cartilage &amp; Chondrocyte Mechanotransduction Cartilage &amp; Chodrocyte Mechanotransduction **Enter your text here** All cells are subjected to mechanical loads from interactions with their environments (e.g. walking or gravity). Several studies have demonstrated that cells change their biological behavior in response to mechanical loading. We use chondrocytes (cartilage cells) as a model system and are interested [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":1091,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"nf_dc_page":"","site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1523","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/pages\/1523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/comments?post=1523"}],"version-history":[{"count":5,"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/pages\/1523\/revisions"}],"predecessor-version":[{"id":1530,"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/pages\/1523\/revisions\/1530"}],"up":[{"embeddable":true,"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/pages\/1091"}],"wp:attachment":[{"href":"https:\/\/junelab.org\/ron\/wp-json\/wp\/v2\/media?parent=1523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}